The association of adverse outcomes with pregnancy conception methods among low-risk term pregnancies

ObjectiveTo compare composite neonatal and maternal adverse outcomes among low-risk singleton pregnancies at 37–41 weeks conception methods: spontaneously-conceived (SC) pregnancy; infertility medications and/or intrauterine insemination (IFM/IUI); assisted reproductive technology (ART).DesignPopulation-based retrospective cohort study.SettingUS Vital Statistics datasets 2013–2017.Patient(s)Low-risk (without hypertensive disorders, pregestational or gestational diabetes, history of preterm birth) women ≥20 years with nonanomalous singletons, who labored, delivered weeks, had data on pregnancy method.Intervention(s)None.Main Outcome Measure(s)The primary outcome was the (CNAO). The secondary (CMAO).Result(s)Of 19.7 million deliveries during study period, 54.0% (N = 10,676,184) met inclusion criteria, 99.0% 10,573,741) being conceived spontaneously, 0.4% 47,227) by IFM/IUI, 0.5% 55,216) ART. overall rate CNAO 6.68 per 1,000 live births. Compared SC, risk significantly higher IFM/IUI (adjusted relative [aRR], 1.29; 95% CI, 1.18–1.41) ART (aRR, 1.18–1.39). CMAO 2.50 increased 1.72; 1.50–1.97) 2.40; 2.17–2.65).Conclusion(s)Among term pregnancies, have modestly rates to maternal-neonatal dyad than SC. To (ART). Population-based study. US 2013–2017. Low-risk method. None. (CMAO). Of 2.17–2.65). Among